| http://purl.uniprot.org/citations/16897187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16897187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16897187 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor p53 plays a crucial role in the cellular response to DNA damage by transcriptional activation of numerous downstream genes. Although a considerable number of p53 target genes have been reported, the precise mechanism of p53-regulated tumor suppression still remains to be elucidated. Here, we report a novel role of the DFNA5 gene in p53-mediated etoposide-induced cell death. The DFNA5 gene has been previously reported to be responsible for autosomal-dominant, nonsyndromic hearing impairment. The expression of the DFNA5 gene was strongly induced by exogenous and endogenous p53. The chromatin immunoprecipitation assay indicated that a potential p53-binding sequence is located in intron 1 of the DFNA5 gene. Furthermore, the reporter gene assay revealed that the sequence displays p53-dependent transcriptional activity. The ectopic expression of DFNA5 enhanced etoposide-induced cell death in the presence of p53; however, it was inhibited in the absence of p53. Finally, the expression of DFNA5 mRNA was remarkably induced by gamma-ray irradiation in the colon of p53(+/+) mice but not in that of p53(-/-) mice. These results suggest that DFNA5 plays a role in the p53-regulated cellular response to genotoxic stress probably by cooperating with p53."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10038-006-0004-6"xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10038-006-0004-6"xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Arakawa H."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Arakawa H."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Futamura M."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Futamura M."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Masuda Y."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Masuda Y."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Kiyono T."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Kiyono T."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Ohki M."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Ohki M."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Miyamoto Y."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Miyamoto Y."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Kitamura N."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Kitamura N."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Baba H."xsd:string |
| http://purl.uniprot.org/citations/16897187 | http://purl.uniprot.org/core/author | "Baba H."xsd:string |