| http://purl.uniprot.org/citations/16899217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16899217 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently identified a novel actin cytoskeleton-associated protein magicin, for merlin and Grb2 interacting cytoskeletal protein. To unravel the cellular functions of magicin, we used a yeast two-hybrid system and identified Fyn tyrosine kinase as a specific binding partner for magicin. Fyn phosphorylates magicin in vitro. In addition to Fyn, Src and Lck also interact with magicin. Upon stimulation with anti-CD3 antibody, magicin is phosphorylated in the T lymphocyte leukemia Jurkat cell line. Magicin phosphorylation is not observed in an Lck-deficient line, J.CaM1.6, indicating that Lck is the major Src family kinase for phosphorylating magicin in Jurkat cells. Employing site-directed mutagenesis along with in vitro kinase assays, we found that Y64 of magicin is phosphorylated by Lck creating a SH2-Grb2 binding motif. Magicin has also been identified as a Mediator subunit (MED28) in the nucleus involved in transcriptional regulation, therefore we propose that magicin may serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.07.126"xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/author | "Lee M.F."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/author | "Gusella J.F."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/author | "Ramesh V."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/author | "Beyer K.S."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/author | "Beauchamp R.L."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/pages | "826-831"xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/title | "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation."xsd:string |
| http://purl.uniprot.org/citations/16899217 | http://purl.uniprot.org/core/volume | "348"xsd:string |
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