| http://purl.uniprot.org/citations/16899536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16899536 | http://www.w3.org/2000/01/rdf-schema#comment | "In C. elegans one-cell embryos, polarity is conventionally defined along the anteroposterior axis by the segregation of partitioning-defective (PAR) proteins into anterior (PAR-3, PAR-6) and posterior (PAR-1, PAR-2) cortical domains. The establishment of PAR asymmetry is coupled with acto-myosin cytoskeleton rearrangements. The small GTPases RHO-1 and CDC-42 are key players in cytoskeletal remodeling and cell polarity in a number of different systems. We investigated the roles of these two GTPases and the RhoGEF ECT-2 in polarity establishment in C. elegans embryos. We show that CDC-42 is required to remove PAR-2 from the cortex at the end of meiosis and to localize PAR-6 to the cortex. By contrast, RHO-1 activity is required to facilitate the segregation of CDC-42 and PAR-6 to the anterior. Loss of RHO-1 activity causes defects in the early organization of the myosin cytoskeleton but does not inhibit segregation of myosin to the anterior. We therefore propose that RHO-1 couples the polarization of the acto-myosin cytoskeleton with the proper segregation of CDC-42, which, in turn, localizes PAR-6 to the anterior cortex."xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02527"xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/author | "Schonegg S."xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/pages | "3507-3516"xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/title | "CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/16899536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16899536 |
| http://purl.uniprot.org/citations/16899536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16899536 |
| http://purl.uniprot.org/uniprot/#_Q22038-mappedCitation-16899536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16899536 |
| http://purl.uniprot.org/uniprot/#_Q05062-mappedCitation-16899536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16899536 |
| http://purl.uniprot.org/uniprot/Q05062 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16899536 |
| http://purl.uniprot.org/uniprot/Q22038 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16899536 |