| http://purl.uniprot.org/citations/16901543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16901543 | http://www.w3.org/2000/01/rdf-schema#comment | "CD95/Fas and CD40 receptors are important regulators of cell survival during germinal center reaction. In this study we used a human follicular lymphoma cell line, HF1A3, to study molecular mechanisms of CD95-mediated apoptosis and CD40-induced rescue from apoptosis. CD95 stimulation induced activation of caspase-8 and -3, collapse of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and fragmentation of nuclear DNA. All these apoptotic events were abrogated, when cells were pretreated with CD40 antibodies before CD95 stimulation. CD40 induced a rapid up regulation of both short and long isoforms of c-FLIP, as these proteins were detectable 4h after receptor stimulation. The induction of c-FLIP as well as the anti-apoptotic function of CD40 was completely abolished when NF-kappaB activity was inhibited by a selective inhibitor PDTC. We conclude that the anti-apoptotic signaling of CD40 involves NF-kappaB-mediated induction of c-FLIP proteins which can interfere with caspase-8 activation. However, it remains to be seen whether c-FLIP proteins are the only one ones involved in CD40-mediated protection."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2006.06.005"xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Pelkonen J."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Ropponen A."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Eeva J."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Eeva S.T."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Eray M."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Matto M."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/author | "Nuutinen U."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/pages | "1230-1237"xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/title | "The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP."xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/16901543 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16901543 |
| http://purl.uniprot.org/citations/16901543 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16901543 |
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