| http://purl.uniprot.org/citations/16901991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16901991 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of Slc26a6 (PAT1) on apical Cl-/HCO3-exchange and bicarbonate secretion in pancreatic duct cells was investigated using Slc26a6 null and wild-type (WT) mice. Apical Cl-/HCO3-exchange activity was measured with the pH-sensitive dye BCECF in microperfused interlobular ducts. The HCO3(-)-influx mode of apical [Cl-]i/[HCO3-]o exchange (where brackets denote concentration and subscripts i and o denote intra- and extracellular, respectively) was dramatically upregulated in Slc26a6 null mice (P < 0.01 vs. WT), whereas the HCO3(-)-efflux mode of apical [Cl-]o/[HCO3-]i exchange was decreased in Slc26a6 null mice (P < 0.05 vs. WT), suggesting the unidirectionality of the Slc26a6-mediated HCO3-transport. Fluid secretory rate in interlobular ducts were comparable in WT and Slc26a6 null mice (P > 0.05). In addition, when pancreatic juice was collected from whole animal in basal and secretin-stimulated conditions, neither juice volume nor its pH showed differences between WT and Slc26a6 null mice. Semiquantitative RT-PCR demonstrated more than fivefold upregulation in Slc26a3 (DRA) expression in Slc26a6 knockout pancreas. In conclusion, these results point to the role of Slc26a6 in HCO3-efflux at the apical membrane and also suggest the presence of a robust Slc26a3 compensatory upregulation, which can replace the function of Slc26a6 in pancreatic ducts."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00286.2006"xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Yamamoto A."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Lee M.G."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Soleimani M."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Ishiguro H."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Namkung W."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/author | "Worrell R.T."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/pages | "G447-55"xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/title | "Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct."xsd:string |
| http://purl.uniprot.org/citations/16901991 | http://purl.uniprot.org/core/volume | "292"xsd:string |
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