| http://purl.uniprot.org/citations/16903774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16903774 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundInterleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system.Methods and findingsIn the present study, freshly obtained human peripheral blood mononuclear cells were stimulated with different Toll-like receptor (TLR) agonists, and gene expression and synthesis of IL-32 was determined. We demonstrate that the TLR4 agonist lipopolysaccharide induces moderate (4-fold) production of IL-32, whereas agonists of TLR2, TLR3, TLR5, or TLR9, each of which strongly induced tumor necrosis factor alpha and IL-6, did not stimulate IL-32 production. However, the greatest amount of IL-32 was induced by the mycobacteria Mycobacterium tuberculosis and M. bovis BCG (20-fold over unstimulated cells). IL-32-induced synthesis by either lipopolysaccharide or mycobacteria remains entirely cell-associated in monocytes; moreover, steady-state mRNA levels are present in unstimulated monocytes without translation into IL-32 protein, similar to other cytokines lacking a signal peptide. IL-32 production induced by M. tuberculosis is dependent on endogenous interferon-gamma (IFNgamma); endogenous IFNgamma is, in turn, dependent on M. tuberculosis-induced IL-18 via caspase-1.ConclusionsIn conclusion, IL-32 is a cell-associated proinflammatory cytokine, which is specifically stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of IFNgamma."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pmed.0030277"xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Meng X."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Yoon D.Y."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Ottenhoff T."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Netea M.G."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Dinarello C.A."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Joosten L.A."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Chan E.D."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Azam T."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Lewis E.C."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/author | "Langenberg D."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/name | "PLoS Med"xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/pages | "e277"xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/title | "Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/16903774 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16903774 |
| http://purl.uniprot.org/citations/16903774 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16903774 |
| http://purl.uniprot.org/uniprot/#_A8K249-mappedCitation-16903774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16903774 |
| http://purl.uniprot.org/uniprot/#_A8K257-mappedCitation-16903774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16903774 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-16903774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16903774 |