| http://purl.uniprot.org/citations/16905128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16905128 | http://www.w3.org/2000/01/rdf-schema#comment | "The double-stranded RNA binding protein Staufen is required for the microtubule-dependent localization of bicoid and oskar mRNAs to opposite poles of the Drosophila oocyte and also mediates the actin-dependent localization of prospero mRNA during the asymmetric neuroblast divisions. The posterior localization of oskar mRNA requires Staufen RNA binding domain 2, whereas prospero mRNA localization mediated the binding of Miranda to RNA binding domain 5, suggesting that different Staufen domains couple mRNAs to distinct localization pathways. Here, we show that the expression of Miranda during mid-oogenesis targets Staufen/oskar mRNA complexes to the anterior of the oocyte, resulting in bicaudal embryos that develop an abdomen and pole cells instead of the head and thorax. Anterior Miranda localization requires microtubules, rather than actin, and depends on the function of Exuperantia and Swallow, indicating that Miranda links Staufen/oskar mRNA complexes to the bicoid mRNA localization pathway. Since Miranda is expressed in late oocytes and bicoid mRNA localization requires the Miranda-binding domain of Staufen, Miranda may play a redundant role in the final step of bicoid mRNA localization. Our results demonstrate that different Staufen-interacting proteins couple Staufen/mRNA complexes to distinct localization pathways and reveal that Miranda mediates both actin- and microtubule-dependent mRNA localization."xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.05.029"xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/author | "Adams J."xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/author | "Chang C.W."xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/author | "Irion U."xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/author | "St Johnston D."xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/pages | "522-533"xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/title | "Miranda couples oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway."xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/16905128 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16905128 |
| http://purl.uniprot.org/citations/16905128 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16905128 |
| http://purl.uniprot.org/uniprot/P28750#attribution-3CB8013F345A5E4DA4105CDB515419BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/P25159#attribution-39CE1E4C1EB37B7DCEA466E41D858939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/P25159#attribution-3CB8013F345A5E4DA4105CDB515419BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/P40688#attribution-3CB8013F345A5E4DA4105CDB515419BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/Q8IN63#attribution-39CE1E4C1EB37B7DCEA466E41D858939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/O44224#attribution-39CE1E4C1EB37B7DCEA466E41D858939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/Q9VDR7#attribution-39CE1E4C1EB37B7DCEA466E41D858939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/A0A0B4KHS3#attribution-39CE1E4C1EB37B7DCEA466E41D858939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/O45116#attribution-39CE1E4C1EB37B7DCEA466E41D858939 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG06-mappedCitation-16905128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16905128 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS3-mappedCitation-16905128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16905128 |