| http://purl.uniprot.org/citations/16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16906130 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of cytochrome c (Cyt c) in caspase activation has largely been established from mammalian cell-culture studies, but much remains to be learned about its physiological relevance in situ. The role of Cyt c in invertebrates has been subject to considerable controversy. The Drosophila genome contains distinct cyt c genes: cyt c-p and cyt c-d. Loss of cyt c-p function causes embryonic lethality owing to a requirement of the gene for mitochondrial respiration. By contrast, cyt c-d mutants are viable but male sterile. Here, we show that cyt c-d regulates developmental apoptosis in the pupal eye. cyt c-d mutant retinas show a profound delay in the apoptosis of superfluous interommatidial cells and perimeter ommatidial cells. Furthermore, there is no apoptosis in mutant retinal tissues for the Drosophila homologues of apoptotic protease-activating factor 1 (Ark) and caspase 9 (Dronc). In addition, we found that cyt c-d--as with ark and dronc-regulates scutellar bristle number, which is known to depend on caspase activity. Collectively, our results indicate a role of Cyt c in caspase regulation of Drosophila somatic cells."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400773"xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Brown S."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Srivastava M."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Steller H."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Arama E."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Bergmann A."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Mollereau B."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Scherr H."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/author | "Mendes C.S."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/pages | "933-939"xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/title | "Cytochrome c-d regulates developmental apoptosis in the Drosophila retina."xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16906130 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16906130 |
| http://purl.uniprot.org/citations/16906130 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16906130 |
| http://purl.uniprot.org/uniprot/P04657#attribution-289D44007E1F0FEB395B4283554C273F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16906130 |
| http://purl.uniprot.org/uniprot/#_M9NFP7-mappedCitation-16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16906130 |
| http://purl.uniprot.org/uniprot/#_O01382-mappedCitation-16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16906130 |
| http://purl.uniprot.org/uniprot/#_O02002-mappedCitation-16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16906130 |
| http://purl.uniprot.org/uniprot/#_P22815-mappedCitation-16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16906130 |
| http://purl.uniprot.org/uniprot/#_P18824-mappedCitation-16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16906130 |
| http://purl.uniprot.org/uniprot/#_M9PGG4-mappedCitation-16906130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16906130 |