| http://purl.uniprot.org/citations/16906166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16906166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16906166 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies have focused on the events that influence the development of interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) associated with autoimmunity, such as experimental autoimmune encephalitis, but relatively little is known about the cytokines that antagonize T(H)-17 cell effector responses. Here we show that IL-27 receptor-deficient mice chronically infected with Toxoplasma gondii developed severe neuroinflammation that was CD4+ T cell dependent and was associated with a prominent IL-17 response. In vitro, treatment of naive primary T cells with IL-27 suppressed the development T(H)-17 cells induced by IL-6 and transforming growth factor-beta, which was dependent on the intracellular signaling molecule STAT1 but was independent of inhibition of IL-6 signaling mediated by the suppressor protein SOCS3. Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1376"xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1376"xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Huang E."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Huang E."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Huang Q."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Huang Q."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Hunter C.A."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Hunter C.A."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Ernst M."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Ernst M."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Johnson L.M."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Johnson L.M."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Saris C.J.M."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Saris C.J.M."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "O'Shea J.J."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "O'Shea J.J."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Villarino A.V."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Villarino A.V."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Hennighausen L."xsd:string |
| http://purl.uniprot.org/citations/16906166 | http://purl.uniprot.org/core/author | "Hennighausen L."xsd:string |