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http://purl.uniprot.org/citations/16907986http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16907986http://www.w3.org/2000/01/rdf-schema#comment"

Background

The coexistence of endometrial and immune cells during decidualization is preserved by the ability of endometrial cells to regulate the cytotoxic immune activity and their capability to be resistant to immune-mediated apoptosis. These phenomena enable the survival of endometrial ectopic cells. RCAS1 is responsible for regulation of cytotoxic activity. Metallothionein expression seems to protect endometrial cells against apoptosis. The aim of the present study was to evaluate RCAS1 and metallothionein expression in human ovarian and scar endometriomas in relation to the presence of immune cells and their activity.

Methods

Metallothionein, RCAS1, CD25, CD69, CD56, CD16, CD68 antigen expression was assessed by immunohistochemistry in ovarian and scar endometriomas tissue samples which were obtained from 33 patients. The secretory endometrium was used as a control group (15 patients).

Results

The lowest metallothionein expression was revealed in ovarian endometriomas in comparison to scar endometriomas and to the control group. RCAS1 expression was at the highest level in the secretory endometrium and it was at comparable levels in ovarian and scar endometriomas. Similarly, the number of CD56-positive cells was lower in scar and ovarian endometriomas than in the secretory endometrium. The highest number of macrophages was found in ovarian endometriomas. RCAS1-positive macrophages were observed only in ovarian endometriomas. CD25 and CD69 antigen expression was higher in scar and ovarian endometriomas than in the control group.

Conclusion

The expression of RCAS1 and metallothionein by endometrial cells may favor the persistence of these cells in ectopic localization both in scar following cesarean section and in ovarian endometriosis."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.org/dc/terms/identifier"doi:10.1186/1477-7827-4-41"xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Lazar A."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Banas T."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Popiela T."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Dutsch-Wicherek M."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Wicherek L."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Galazka K."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/author"Kleinrok-Podsiadlo B."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/name"Reprod Biol Endocrinol"xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/pages"41"xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/title"Comparison of RCAS1 and metallothionein expression and the presence and activity of immune cells in human ovarian and abdominal wall endometriomas."xsd:string
http://purl.uniprot.org/citations/16907986http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/16907986http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16907986
http://purl.uniprot.org/citations/16907986http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16907986
http://purl.uniprot.org/uniprot/#_Q6R3F1-mappedCitation-16907986http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16907986
http://purl.uniprot.org/uniprot/#_O00559-mappedCitation-16907986http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16907986
http://purl.uniprot.org/uniprot/Q6R3F1http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16907986
http://purl.uniprot.org/uniprot/O00559http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16907986