| http://purl.uniprot.org/citations/16908671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16908671 | http://www.w3.org/2000/01/rdf-schema#comment | "Plectin is a major intermediate filament (IF)-based cytolinker protein that stabilizes cells and tissues mechanically, regulates actin filament dynamics, and serves as a scaffolding platform for signaling molecules. In this study, we show that plectin deficiency is a cause of aberrant keratin cytoskeleton organization caused by a lack of orthogonal IF cross-linking. Keratin networks in plectin-deficient cells were more susceptible to osmotic shock-induced retraction from peripheral areas, and their okadaic acid-induced disruption (paralleled by stress-activated MAP kinase p38 activation) proceeded faster. Basal activities of the MAP kinase Erk1/2 and of the membrane-associated upstream protein kinases c-Src and PKCdelta were significantly elevated, and increased migration rates, as assessed by in vitro wound-closure assays and time-lapse microscopy, were observed. Forced expression of RACK1, which is the plectin-binding receptor protein for activated PKCdelta, in wild-type keratinocytes elevated their migration potential close to that of plectin-null cells. These data establish a link between cytolinker-controlled cytoarchitecture/scaffolding functions of keratin IFs and specific MAP kinase cascades mediating distinct cellular responses."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200605172"xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/author | "Wiche G."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/author | "Reipert S."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/author | "Gregor M."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/author | "Walko G."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/author | "Burgstaller G."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/author | "Osmanagic-Myers S."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/pages | "557-568"xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/title | "Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration."xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/16908671 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16908671 |
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