| http://purl.uniprot.org/citations/16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16908858 | http://www.w3.org/2000/01/rdf-schema#comment | "The master regulator of MHC-II gene transcription, class II transactivator (CIITA), acts as a potent inhibitor of human T cell leukemia virus type 2 (HTLV-2) replication by blocking the activity of the viral Tax-2 transactivator. Here, we show that this inhibitory effect takes place at the nuclear level and maps to the N-terminal 1-321 region of CIITA, where we identified a minimal domain, from positions 64-144, that is strictly required to suppress Tax-2 function. Furthermore, we show that Tax-2 specifically cooperates with cAMP response element binding protein-binding protein (CBP) and p300, but not with p300/CBP-associated factor, to enhance transcription from the viral promoter. This finding represents a unique difference with respect to Tax-1, which uses all three coactivators to transactivate the human T cell leukemia virus type 1 LTR. Direct sequestering of CBP or p300 is not the primary mechanism by which CIITA causes suppression of Tax-2. Interestingly, we found that the transcription factor nuclear factor Y, which interacts with CIITA to increase transcription of MHC-II genes, exerts a negative regulatory action on the Tax-2-mediated HTLV-2 LTR transactivation. Thus, CIITA may inhibit Tax-2 function, at least in part, through nuclear factor Y. These findings demonstrate the dual defensive role of CIITA against pathogens: it increases the antigen-presenting function for viral determinants and suppresses HTLV-2 replication in infected cells."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0601589103"xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/author | "Mortara L."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/author | "Tosi G."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/author | "Accolla R.S."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/author | "Casoli C."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/author | "Pilotti E."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/author | "De Lerma Barbaro A."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/pages | "12861-12866"xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/title | "Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y."xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/16908858 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16908858 |
| http://purl.uniprot.org/citations/16908858 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16908858 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHC7-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
| http://purl.uniprot.org/uniprot/#_A0A2R8W6Z7-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
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| http://purl.uniprot.org/uniprot/#_Q3UNW8-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
| http://purl.uniprot.org/uniprot/#_P79621-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
| http://purl.uniprot.org/uniprot/#_Q3KND9-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
| http://purl.uniprot.org/uniprot/#_Q3KNE0-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
| http://purl.uniprot.org/uniprot/#_Q3TR57-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |
| http://purl.uniprot.org/uniprot/#_Q3U2P0-mappedCitation-16908858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16908858 |