| http://purl.uniprot.org/citations/16914507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16914507 | http://www.w3.org/2000/01/rdf-schema#comment | "CD1d-restricted NKT cells are activated by TCR-mediated stimulation via CD1d plus lipid antigens such as alpha-galactosylceramide (alpha-GalCer). These cells suppressed autoimmunity and graft rejection, but sometimes enhanced resistance to infection and tumor immunity. This double-action phenomenon of NKT cells is partly explained by cytokines produced by NKT cells. Therefore, roles of cytokines from activated NKT cells have been extensively examined; however, their roles on T cell homeostatic proliferation in lymphopenic condition have not been investigated. Here, we showed that alpha-GalCer enhanced homeostatic proliferation of CD8+ but not CD4+ T cells and this effect of alpha-GalCer was required for NKT cells. IL-4 was essential and sufficient for this NKT cell action on CD8+ T cell homeostatic proliferation. Importantly, the expression of IL-4Ralpha and STAT6 in CD8+ T cells was essential for the NKT activity, indicating a direct action of IL-4 on CD8+ T cells. Consistent with this, the level of IL-4Ralpha expression on memory phenotype CD8(+) T cells was higher than that on naive phenotype one and CD4+ T cells. Thus, these results showed the 'involvement' of IL-4 that is produced from activated NKT cells for CD8+ T cell homeostatic proliferation in vivo."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxl073"xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Sawa S."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Tashiro T."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Ueda N."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Seino K."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Kamimura D."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Fushuku K."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/author | "Kuki H."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/pages | "1397-1404"xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/title | "CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4."xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/16914507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16914507 |
| http://purl.uniprot.org/citations/16914507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16914507 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-16914507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16914507 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNW1-mappedCitation-16914507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16914507 |
| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-16914507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16914507 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-16914507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16914507 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-16914507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16914507 |