| http://purl.uniprot.org/citations/16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16916642 | http://www.w3.org/2000/01/rdf-schema#comment | "The homeodomain protein TGIF has been implicated in the negative regulation of TGF-beta signaling. In this study, we report an unexpected role of TGIF in the inhibition of Smad2 phosphorylation, which occurs by a mechanism independent of its association with Smad2. This inhibitory function of TGIF is executed in concert with c-Jun, which facilitates the interaction of TGIF with cPML, resulting in the nuclear sequestration of cPML and the disruption of the cPML-SARA complex. Notably, knockdown of TGIF by siRNA caused increased association of cPML with SARA and cytoplasmic accumulation of cPML. Furthermore, c-Jun(-/-) fibroblasts exhibit enhanced association of cPML with SARA. c-Jun(-/-) fibroblasts also lose their sensitivity to TGIF-mediated disruption of the cPML-SARA complex and of nuclear sequestration of cPML. We suggest that the interaction of TGIF with cPML through c-Jun may negatively regulate TGF-beta signaling through controlling the localization of cPML and, consequently, the assembly of the cPML-SARA complex."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2006.06.018"xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Prunier C."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Seo S.R."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Atfi A."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Ferrand N."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Pessah M."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Bourgeade M.F."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Abecassis L."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/author | "Faresse N."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/pages | "547-559"xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/title | "Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/16916642 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16916642 |
| http://purl.uniprot.org/citations/16916642 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16916642 |
| http://purl.uniprot.org/uniprot/P05627#attribution-A392EDD9FBEC0B606E9982692E3DB997 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16916642 |
| http://purl.uniprot.org/uniprot/#_A0A087WNP4-mappedCitation-16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16916642 |
| http://purl.uniprot.org/uniprot/#_A0A068EW80-mappedCitation-16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16916642 |
| http://purl.uniprot.org/uniprot/#_D3Z0Q5-mappedCitation-16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16916642 |
| http://purl.uniprot.org/uniprot/#_E0CYI0-mappedCitation-16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16916642 |
| http://purl.uniprot.org/uniprot/#_D3YXR5-mappedCitation-16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16916642 |
| http://purl.uniprot.org/uniprot/#_Q15583-mappedCitation-16916642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16916642 |