| http://purl.uniprot.org/citations/16917499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16917499 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DC) play a central role in immune responses by presenting antigenic peptides to CD4+ T cells through MHCII molecules. Here, we demonstrate a TRIF-GEFH1-RhoB pathway is involved in MHCII surface expression on DC. We show the TRIF (TIR domain-containing adapter inducing IFNbeta)-but not the myeloid differentiation factor 88 (MyD88)-dependent pathway of lipopolysaccharide (LPS)-signaling in DC is crucial for the MHCII surface expression, followed by CD4+ T-cell activation. LPS increased the activity of RhoB, but not of RhoA, Cdc42, or Rac1/2 in a manor dependent on LPS-TRIF-but not LPS-Myd88-signaling. RhoB colocalized with MHCII+ lysosomes in DC. A dominant-negative (DN) form of RhoB (DN-RhoB) or RhoB's RNAi in DC inhibited the LPS-induced MHCII surface expression. Moreover, we found GEFH1 associated with RhoB, and DN-GEFH1 or GEFH1's RNAi suppressed the LPS-mediated RhoB activation and MHCII surface expression. DN-RhoB attenuated the DC's CD4+ T-cell stimulatory activity. Thus, our results provide a molecular mechanism relating how the MHCII surface expression is regulated during the maturation stage of DC. The activation of GEFH1-RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601286"xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Kitamura H."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Kawabe T."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Kaisho T."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Kamimura D."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/author | "Kamon H."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/pages | "4108-4119"xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/title | "TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation."xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16917499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16917499 |
| http://purl.uniprot.org/citations/16917499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16917499 |
| http://purl.uniprot.org/uniprot/#_P52735-mappedCitation-16917499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16917499 |
| http://purl.uniprot.org/uniprot/#_O15085-mappedCitation-16917499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16917499 |
| http://purl.uniprot.org/uniprot/#_P62745-mappedCitation-16917499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16917499 |
| http://purl.uniprot.org/uniprot/#_P62746-mappedCitation-16917499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16917499 |