| http://purl.uniprot.org/citations/16917503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16917503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16917503 | http://www.w3.org/2000/01/rdf-schema#comment | "This study identified CD63, a member of the tetraspanin family, as a TIMP-1 interacting protein by yeast two-hybrid screening. Immunoprecipitation and confocal microscopic analysis confirmed CD63 interactions with TIMP-1, integrin beta1, and their co-localizations on the cell surface of human breast epithelial MCF10A cells. TIMP-1 expression correlated with the level of active integrin beta1 on the cell surface independent of cell adhesion. While MCF10A cells within a three-dimensional (3D) matrigel matrix form polarized acinar-like structures, TIMP-1 overexpression disrupted breast epithelial cell polarization and inhibited caspase-mediated apoptosis in centrally located cells, necessary for the formation and maintenance of the hollow acinar-like structures. Small hairpin RNA (shRNA)-mediated CD63 downregulation effectively reduced TIMP-1 binding to the cell surface, TIMP-1 co-localization with integrin beta1, and consequently reversed TIMP-1-mediated integrin beta1 activation, cell survival signaling and apoptosis inhibition. CD63 downregulation also restored polarization and apoptosis of TIMP-1 overexpressing MCF10A cells within a 3D-matrigel matrix. Taken together, the present study identified CD63 as a cell surface binding partner for TIMP-1, regulating cell survival and polarization via TIMP-1 modulation of tetraspanin/integrin signaling complex."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601281"xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601281"xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Liu X.W."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Liu X.W."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Chirco R."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Chirco R."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Fridman R."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Fridman R."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Jung K.K."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/author | "Jung K.K."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/pages | "3934-3942"xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/pages | "3934-3942"xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/title | "Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/title | "Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16917503 | http://purl.uniprot.org/core/volume | "25"xsd:string |