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http://purl.uniprot.org/citations/16919269http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16919269http://www.w3.org/2000/01/rdf-schema#comment"Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.org/dc/terms/identifier"doi:10.1016/j.yexcr.2006.06.017"xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Lenhard B."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Sandelin A."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Andersson E."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Ericson J."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Muhr J."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Karlen M."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Bailey P.J."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Klos J.M."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Kallstrom M."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/author"Ponjavic J."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/name"Exp Cell Res"xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/pages"3108-3119"xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/title"A global genomic transcriptional code associated with CNS-expressed genes."xsd:string
http://purl.uniprot.org/citations/16919269http://purl.uniprot.org/core/volume"312"xsd:string
http://purl.uniprot.org/citations/16919269http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16919269
http://purl.uniprot.org/citations/16919269http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16919269
http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-16919269http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16919269
http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-16919269http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16919269
http://purl.uniprot.org/uniprot/#_A0A0A6YVY5-mappedCitation-16919269http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16919269
http://purl.uniprot.org/uniprot/#_A0A0A6YW74-mappedCitation-16919269http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16919269
http://purl.uniprot.org/uniprot/#_A0A0A6YW90-mappedCitation-16919269http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16919269