| http://purl.uniprot.org/citations/16919435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/16919435 | http://www.w3.org/2000/01/rdf-schema#comment | "Integrins can alter cellular behavior through the recruitment and activation of signaling proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c-Src that form a dual kinase complex. The FAK-Src complex binds to and can phosphorylate various adaptor proteins such as p130Cas and paxillin. In normal cells, multiple integrin-regulated linkages exist to activate FAK or Src. Activated FAK-Src functions to promote cell motility, cell cycle progression and cell survival. Recent studies have found that the FAK-Src complex is activated in many tumor cells and generates signals leading to tumor growth and metastasis. As both FAK and Src catalytic activities are important in promoting VEGF-associated tumor angiogenesis and protease-associated tumor metastasis, support is growing that FAK and Src may be therapeutically relevant targets in the inhibition of tumor progression."xsd:string |
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| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/author | "Schlaepfer D.D."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/author | "Schlaepfer D.D."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/author | "Mitra S.K."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/author | "Mitra S.K."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/name | "Curr. Opin. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/name | "Curr. Opin. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/pages | "516-523"xsd:string |
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| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/title | "Integrin-regulated FAK-Src signaling in normal and cancer cells."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/title | "Integrin-regulated FAK-Src signaling in normal and cancer cells."xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/16919435 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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