| http://purl.uniprot.org/citations/16919458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16919458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16919458 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that participates in at least two distinct multiprotein complexes, mTORC1 and mTORC2 . These complexes play important roles in the regulation of cell growth, proliferation, survival, and metabolism. mTORC2 is a hydrophobic motif kinase for the cell-survival protein Akt/PKB and, here, we identify mSin1 as a component of mTORC2 but not mTORC1. mSin1 is necessary for the assembly of mTORC2 and for its capacity to phosphorylate Akt/PKB. Alternative splicing generates at least five isoforms of the mSin1 protein , three of which assemble into mTORC2 to generate three distinct mTORC2s. Even though all mTORC2s can phosphorylate Akt/PKB in vitro, insulin regulates the activity of only two of them. Thus, we propose that cells contain several mTORC2 flavors that may phosphorylate Akt/PKB in response to different signals."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.08.001"xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.08.001"xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Sabatini D.M."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Sabatini D.M."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Jaffe J.D."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Jaffe J.D."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Carr S.A."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Carr S.A."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Thoreen C.C."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Thoreen C.C."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Sculley T."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Sculley T."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Schroder W."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Schroder W."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Frias M.A."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/author | "Frias M.A."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/pages | "1865-1870"xsd:string |
| http://purl.uniprot.org/citations/16919458 | http://purl.uniprot.org/core/pages | "1865-1870"xsd:string |