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| http://purl.uniprot.org/citations/16919487 | http://www.w3.org/2000/01/rdf-schema#comment | "Molecular mechanisms underlying the coordination of isotype switching with plasma cell differentiation are poorly understood. We show that interferon regulatory factor-4 (IRF-4) regulates both processes by controlling the expression of the Aicda and Prdm1 genes, which encode AID and Blimp-1, respectively. Genome-wide analysis demonstrated that Irf4(-/-) B cells failed to induce the entire Blimp-1-dependent plasma cell program. Restoration of AID or Blimp-1 expression in Irf4(-/-) B cells promoted isotype switching or secretion, respectively. IRF-4 was expressed in a graded manner in differentiating B cells and targeted Prdm1. Higher concentration of IRF-4 induced Prdm1 and consequently the transition from a germinal center gene expression program to that of a plasma cell. We propose a gene-regulatory network in which graded expression of IRF-4 developmentally coordinates isotype switching with plasma cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.07.009"xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/author | "Shaffer A.L."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/author | "Sciammas R."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/author | "Schatz J.H."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/pages | "225-236"xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/title | "Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/16919487 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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