| http://purl.uniprot.org/citations/16920626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16920626 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the widespread clinical use of volatile anesthetics, their mechanisms of action remain unknown [1-6]. An unbiased genetic screen in the nematode C. elegans for animals with altered volatile anesthetic sensitivity identified a mutant in a nuclear-encoded subunit of mitochondrial complex I [7,8]. This raised the question of whether mitochondrial dysfunction might be the primary mechanism by which volatile anesthetics act, rather than an untoward secondary effect [9,10]. We report here analysis of additional C. elegans mutations in orthologs of human genes that contribute to the formation of complex I, complex II, complex III, and coenzyme Q [11-14]. To further characterize the specific contribution of complex I, we generated four hypomorphic C. elegans mutants encoding different complex I subunits [15]. Our main finding is the identification of a clear correlation between complex I-dependent oxidative phosphorylation capacity and volatile anesthetic sensitivity. These extended data link a physiologic determinant of anesthetic action in a tractable animal model to similar clinical observations in children with mitochondrial myopathies [16]. This work is the first to specifically implicate complex I-dependent oxidative phosphorylation function as a primary mediator of volatile anesthetic effect."xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.06.072"xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/author | "Falk M.J."xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/author | "Morgan P.G."xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/author | "Sedensky M.M."xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/author | "Kayser E.B."xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/pages | "1641-1645"xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/title | "Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/16920626 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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