| http://purl.uniprot.org/citations/16920631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16920631 | http://www.w3.org/2000/01/rdf-schema#comment | "A rise in cytosolic Ca(2+) concentration is used as a key activation signal in virtually all animal cells, where it triggers a range of responses including neurotransmitter release, muscle contraction, and cell growth and proliferation [1]. During intracellular Ca(2+) signaling, mitochondria rapidly take up significant amounts of Ca(2+) from the cytosol, and this stimulates energy production, alters the spatial and temporal profile of the intracellular Ca(2+) signal, and triggers cell death [2-10]. Mitochondrial Ca(2+) uptake occurs via a ruthenium-red-sensitive uniporter channel found in the inner membrane [11]. In spite of its critical importance, little is known about how the uniporter is regulated. Here, we report that the mitochondrial Ca(2+) uniporter is gated by cytosolic Ca(2+). Ca(2+) uptake into mitochondria is a Ca(2+)-activated process with a requirement for functional calmodulin. However, cytosolic Ca(2+) subsequently inactivates the uniporter, preventing further Ca(2+) uptake. The uptake pathway and the inactivation process have relatively low Ca(2+) affinities of approximately 10-20 microM. However, numerous mitochondria are within 20-100 nm of the endoplasmic reticulum, thereby enabling rapid and efficient transmission of Ca(2+) release into adjacent mitochondria by InsP(3) receptors on the endoplasmic reticulum. Hence, biphasic control of mitochondrial Ca(2+) uptake by Ca(2+) provides a novel basis for complex physiological patterns of intracellular Ca(2+) signaling."xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.06.059"xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/author | "Nelson C."xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/author | "Moreau B."xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/author | "Parekh A.B."xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/pages | "1672-1677"xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/title | "Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentration."xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/16920631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16920631 |
| http://purl.uniprot.org/citations/16920631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16920631 |
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