| http://purl.uniprot.org/citations/16920909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16920909 | http://www.w3.org/2000/01/rdf-schema#comment | "Although IL-12 and IL-23 share the common p40 subunit, IL-23, rather than IL-12, seems to drive the pathogenesis of experimental autoimmune encephalomyelitis and arthritis, because IL-23/p19 knockout mice are protected from disease. In contrast, we describe in this study that newly created LacZ knockin mice deficient for IL-23 p19 were highly susceptible for the development of experimental T cell-mediated TNBS colitis and showed even more severe colitis than wild-type mice by endoscopic and histologic criteria. Subsequent studies revealed that dendritic cells from p19-deficient mice produce elevated levels of IL-12, and that IL-23 down-regulates IL-12 expression upon TLR ligation. Finally, in vivo blockade of IL-12 p40 in IL-23-deficient mice rescued mice from lethal colitis. Taken together, our data identify cross-regulation of IL-12 expression by IL-23 as novel key regulatory pathway during initiation of T cell dependent colitis."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.5.2760"xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Nikolaev A."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Becker C."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Galle P.R."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Murphy A.J."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Valenzuela D.M."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Yancopoulos G.D."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Neurath M.F."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Huebner S."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Karow M."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Dornhoff H."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Wirtz S."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Fantini M.C."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Neufert C."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/author | "Lehr H.A."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/pages | "2760-2764"xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/title | "Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis."xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/16920909 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16920909 |
| http://purl.uniprot.org/citations/16920909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16920909 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-16920909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16920909 |