| http://purl.uniprot.org/citations/16925675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16925675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16925675 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of many chordate features depends on retinoic acid (RA). Because the action of RA during development seems to be restricted to chordates, it had been previously proposed that the "invention" of RA genetic machinery, including RA-binding nuclear hormone receptors (Rars), and the RA-synthesizing and RA-degrading enzymes Aldh1a (Raldh) and Cyp26, respectively, was an important step for the origin of developmental mechanisms leading to the chordate body plan. We tested this hypothesis by conducting an exhaustive survey of the RA machinery in genomic databases for twelve deuterostomes. We reconstructed the evolution of these genes in deuterostomes and showed for the first time that RA genetic machinery--that is Aldh1a, Cyp26, and Rar orthologs--is present in nonchordate deuterostomes. This finding implies that RA genetic machinery was already present during early deuterostome evolution, and therefore, is not a chordate innovation. This new evolutionary viewpoint argues against the hypothesis that the acquisition of gene families underlying RA metabolism and signaling was a key event for the origin of chordates. We propose a new hypothesis in which lineage-specific duplication and loss of RA machinery genes could be related to the morphological radiation of deuterostomes."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1525-142X.2006.00113.x"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1525-142x.2006.00113.x"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Postlethwait J.H."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Postlethwait J.H."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Gonzalez-Duarte R."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Gonzalez-Duarte R."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Albalat R."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Albalat R."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Canestro C."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/author | "Canestro C."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/name | "Evol. Dev."xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/name | "Evol Dev"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/pages | "394-406"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/pages | "394-406"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/title | "Is retinoic acid genetic machinery a chordate innovation?"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/title | "Is retinoic acid genetic machinery a chordate innovation?"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/16925675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16925675 |
| http://purl.uniprot.org/citations/16925675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16925675 |