| http://purl.uniprot.org/citations/16930548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16930548 | http://www.w3.org/2000/01/rdf-schema#comment | "The low-density lipoprotein receptor-related protein (LRP) is a large, endocytic receptor involved in intracellular signalling. LRP acts as a co-receptor with the PDGF-receptor (PDGF-r) for platelet-derived growth factor (PDGF). PDGF-r and Src-kinases induce tyrosine-phosphorylation of LRP. We used fluorescence lifetime imaging microscopy (FLIM) to specifically detect LRP phosphorylation, measure its extent and localization in intact cells, and assess its effects upon LRP-APP interaction. Robust phosphorylation of LRP throughout the cell was observed after overexpression of Src-kinase. This depended on LRP's distal NPXY domain. By contrast, activation of the PDGF-r resulted in phosphorylation of the subpopulation of LRP at or near the cell surface. PDGF activation triggered phosphorylation of endogenous LRP in primary neurons. LRP is also a trafficking receptor for the Alzheimer-related molecule amyloid-precursor-protein (APP). PDGF stimulation did not affect LRP-APP interactions. This approach allows exquisite subcellular resolution of specific LRP post-translational changes and protein-protein interactions of endogenous proteins in intact cells."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.07.212"xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/author | "Hyman B.T."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/author | "Peltan I.D."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/author | "Thomas A.V."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/author | "von Arnim C.A."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/author | "Mikhailenko I."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/author | "Strickland D.K."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/pages | "24-30"xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/title | "Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons."xsd:string |
| http://purl.uniprot.org/citations/16930548 | http://purl.uniprot.org/core/volume | "349"xsd:string |
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