| http://purl.uniprot.org/citations/16931093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16931093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16931093 | http://www.w3.org/2000/01/rdf-schema#comment | "The dormancy (DosR) regulon of Mycobacterium tuberculosis is expressed in vitro during hypoxia and low-dose nitric oxide stimulation. Tubercle bacilli are thought to encounter these conditions in humans during latent infection. In this study, immune responses were evaluated to 25 most strongly induced DosR-regulon-encoded proteins, referred to as latency antigens. Proliferation assays were performed using M. tuberculosis-specific T-cell lines and peripheral blood mononuclear cells (PBMC) from tuberculosis (TB) patients, tuberculin skin test positive (TST+) individuals and uninfected controls. All 25 latency antigens were able to induce production of interferon-gamma (IFN-gamma) by T-cell lines. Eighteen latency antigens were also recognized by PBMC of M. tuberculosis-infected individuals, which indicates expression of the DosR-regulon during natural infection. Differential analysis showed that TST+ individuals recognized more latency antigens and with a stronger cumulative IFN-gamma response than TB patients, while the opposite profile was found for culture filtrate protein-10. In particular Rv1733c, Rv2029c, Rv2627c and Rv2628 induced strong IFN-gamma responses in TST+ individuals, with 61%, 61%, 52% and 35% responders, respectively. In conclusion, several new M. tuberculosis antigens were identified within the DosR-regulon. Particularly strong IFN-gamma responses to latency antigens were observed in latently infected individuals, suggesting that immune responses against these antigens may contribute to controlling latent M. tuberculosis infection."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micinf.2006.03.018"xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micinf.2006.03.018"xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Schoolnik G.K."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Schoolnik G.K."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Voskuil M.I."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Voskuil M.I."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Andersen P."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Andersen P."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Franken K.L."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Franken K.L."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Klein M.R."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Klein M.R."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Lin M.Y."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Lin M.Y."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Ottenhoff T.H."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Ottenhoff T.H."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Friggen A.H."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Friggen A.H."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Weldingh K."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Weldingh K."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Prins C."xsd:string |
| http://purl.uniprot.org/citations/16931093 | http://purl.uniprot.org/core/author | "Prins C."xsd:string |