| http://purl.uniprot.org/citations/16931600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16931600 | http://www.w3.org/2000/01/rdf-schema#comment | "IkappaB are responsible for maintaining p65 in the cytoplasm under non-stimulating conditions and promoting the active export of p65 from the nucleus following NFkappaB activation to terminate the signal. We now show that 14-3-3 proteins regulate the NFkappaB signaling pathway by physically interacting with p65 and IkappaBalpha proteins. We identify two functional 14-3-3 binding domains in the p65 protein involving residues 38-44 and 278-283, and map the interaction region of IkappaBalpha in residues 60-65. Mutation of these 14-3-3 binding domains in p65 or IkappaBalpha results in a predominantly nuclear distribution of both proteins. TNFalpha treatment promotes recruitment of 14-3-3 and IkappaBalpha to NFkappaB-dependent promoters and enhances the binding of 14-3-3 to p65. Disrupting 14-3-3 activity by transfection with a dominant-negative 14-3-3 leads to the accumulation of nuclear p65-IkappaBalpha complexes and the constitutive association of p65 with the chromatin. In this situation, NFkappaB-dependent genes become unresponsive to TNFalpha stimulation. Together our results indicate that 14-3-3 proteins facilitate the nuclear export of IkappaBalpha-p65 complexes and are required for the appropriate regulation of NFkappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03086"xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/author | "Espinosa L."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/author | "Bigas A."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/author | "Rodilla V."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/author | "Ingles-Esteve J."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/author | "Aguilera C."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/author | "Fernandez-Majada V."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/pages | "3695-3704"xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/title | "Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins."xsd:string |
| http://purl.uniprot.org/citations/16931600 | http://purl.uniprot.org/core/volume | "119"xsd:string |
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