http://purl.uniprot.org/citations/16931762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16931762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16931762 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian intestine harbors complex societies of beneficial bacteria that are maintained in the lumen with minimal penetration of mucosal surfaces. Microbial colonization of germ-free mice triggers epithelial expression of RegIIIgamma, a secreted C-type lectin. RegIIIgamma binds intestinal bacteria but lacks the complement recruitment domains present in other microbe-binding mammalian C-type lectins. We show that RegIIIgamma and its human counterpart, HIP/PAP, are directly antimicrobial proteins that bind their bacterial targets via interactions with peptidoglycan carbohydrate. We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1127119"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1127119"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Hooper L.V."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Hooper L.V."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Behrendt C.L."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Behrendt C.L."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Cash H.L."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Cash H.L."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Whitham C.V."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/author | "Whitham C.V."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/pages | "1126-1130"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/pages | "1126-1130"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/title | "Symbiotic bacteria direct expression of an intestinal bactericidal lectin."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/title | "Symbiotic bacteria direct expression of an intestinal bactericidal lectin."xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/volume | "313"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://purl.uniprot.org/core/volume | "313"xsd:string |
http://purl.uniprot.org/citations/16931762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16931762 |
http://purl.uniprot.org/citations/16931762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16931762 |