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http://purl.uniprot.org/citations/16931762http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16931762http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16931762http://www.w3.org/2000/01/rdf-schema#comment"The mammalian intestine harbors complex societies of beneficial bacteria that are maintained in the lumen with minimal penetration of mucosal surfaces. Microbial colonization of germ-free mice triggers epithelial expression of RegIIIgamma, a secreted C-type lectin. RegIIIgamma binds intestinal bacteria but lacks the complement recruitment domains present in other microbe-binding mammalian C-type lectins. We show that RegIIIgamma and its human counterpart, HIP/PAP, are directly antimicrobial proteins that bind their bacterial targets via interactions with peptidoglycan carbohydrate. We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.org/dc/terms/identifier"doi:10.1126/science.1127119"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.org/dc/terms/identifier"doi:10.1126/science.1127119"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Hooper L.V."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Hooper L.V."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Behrendt C.L."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Behrendt C.L."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Cash H.L."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Cash H.L."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Whitham C.V."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/author"Whitham C.V."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/pages"1126-1130"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/pages"1126-1130"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/title"Symbiotic bacteria direct expression of an intestinal bactericidal lectin."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/title"Symbiotic bacteria direct expression of an intestinal bactericidal lectin."xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/volume"313"xsd:string
http://purl.uniprot.org/citations/16931762http://purl.uniprot.org/core/volume"313"xsd:string
http://purl.uniprot.org/citations/16931762http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16931762
http://purl.uniprot.org/citations/16931762http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16931762