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http://purl.uniprot.org/citations/16935699http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16935699http://www.w3.org/2000/01/rdf-schema#comment"

Aim

We examined the effect of meal fatty acids on lipid and apolipoprotein concentrations of very low density lipoprotein (VLDL) and chylomicron/chylomicron remnants in lipid fractions with a Svedberg flotation rate (Sf) 60-400 and Sf 20-60.

Methods and results

Six healthy middle-aged men received in random order mixed meals enriched with saturated (SFA), polyunsaturated (PUFA) or monounsaturated (MUFA) fatty acids on 3 occasions. VLDL and chylomicron/chylomicron remnants in the lipid fractions were separated by immunoaffinity chromatography against apo B-100. In the Sf 60-400 chylomicron/chylomicron remnants, triacylglycerol and cholesterol concentrations were significantly lower following PUFA compared with SFA and MUFA (P < or = 0.05). Apolipoprotein (apo) E responses were significantly higher after SFA in chylomicron/chylomicron remnants and VLDL compared with PUFA and MUFA (P < 0.007). However, apo B responses (particle number) were higher following MUFA than SFA (P = 0.039 for chylomicron/chylomicron remnants). Composition of the chylomicron/chylomicron remnants (expressed per particle) revealed differences in their triacylglycerol and apo E contents; in the Sf 60-400 fraction, SFA-rich chylomicron/chylomicron remnants contained significantly more triacylglycerol than MUFA (P = 0.028), more apo E than PUFA- and MUFA-rich particles (P < 0.05) and in the Sf 20-60 fraction, more apo E than MUFA (P = 0.009).

Conclusion

There are specific differences in the composition of chylomicron/chylomicron remnants formed after saturated compared with unsaturated fatty acid-rich meals which could determine their metabolic fate in the circulation and subsequent atherogenicity."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.org/dc/terms/identifier"doi:10.1016/j.numecd.2005.07.001"xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/author"Williams C.M."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/author"Jackson K.G."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/author"Yaqoob P."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/author"Bateman P.A."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/author"Wolstencroft E.J."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/name"Nutr Metab Cardiovasc Dis"xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/pages"405-417"xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/title"Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids."xsd:string
http://purl.uniprot.org/citations/16935699http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/16935699http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16935699
http://purl.uniprot.org/citations/16935699http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16935699
http://purl.uniprot.org/uniprot/P02656#attribution-539ED8E6FC42231844161D7D26368D14http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/16935699
http://purl.uniprot.org/uniprot/P02649#attribution-539ED8E6FC42231844161D7D26368D14http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/16935699