| http://purl.uniprot.org/citations/16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16935935 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute promyelocytic leukemia (APL) cells express promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion protein, which leads to the blocking of APL cell differentiation. Treatment of APL with all-trans-retinoic acid (ATRA) induces disease remission by in vivo differentiation of APL cells. Differentiation requires cell cycle exit; yet how ATRA couples cell cycle exit to differentiation of APL remains largely unknown. We previously found that ATRA-induced cell differentiation accompanies ubiquitination-proteolysis of ménage à trois 1 (MAT1), an assembly factor and targeting subunit of cyclin-dependent kinase (CDK)-activating kinase (CAK) that regulates G1 exit. We report here that CAK binds to and phosphorylates PML/RARalpha in actively proliferating APL cells. In response to ATRA, PML/RARalpha is dissociated from CAK, leading to MAT1 degradation, G1 arrest, and decreased CAK phosphorylation of PML/RARalpha. CAK phosphorylation of PML/RARalpha is inhibited when MAT1 levels are reduced. Both MAT1 degradation and PML/RARalpha hypophosphorylation occur in ATRA-induced G1-arresting cells undergoing differentiation but not in the synchronized G1 cells that do not differentiate. These findings reveal a novel ATRA signaling on APL cell differentiation, in which ATRA coordinates G1 arrest and transition into differentiation by inducing MAT1 degradation and PML/RARalpha hypophosphorylation through disrupting PML/RARalpha binding and phosphorylation by CAK."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.06-5900fje"xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Wang J.G."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Weinberg K.I."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Zhang X.K."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Triche T.J."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Davicioni E."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/author | "Barsky L.W."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/pages | "2142-2144"xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/title | "Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha."xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/16935935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16935935 |
| http://purl.uniprot.org/citations/16935935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16935935 |
| http://purl.uniprot.org/uniprot/#_A0A024R688-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z414-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_A4VCI9-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_A8K6Q5-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_B4DTK9-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_B4DV67-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_P51946-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |
| http://purl.uniprot.org/uniprot/#_P51948-mappedCitation-16935935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16935935 |