| http://purl.uniprot.org/citations/16936638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16936638 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional control of hypothalamic thyrotropin-releasing hormone (TRH) integrates central regulation of the hypothalamo-hypophyseal-thyroid axis and hence thyroid hormone (triiodothyronine (T(3))) homeostasis. The two beta thyroid hormone receptors, TRbeta1 and TRbeta2, contribute to T(3) feedback on TRH, with TRbeta1 having a more important role in the activation of TRH transcription. How TRbeta1 fulfils its role in activating TRH gene transcription is unknown. By using a yeast two-hybrid screening of a mouse hypothalamic complementary DNA library, we identified a novel partner for TRbeta1, hepatitis virus B X-associated protein 2 (XAP2), a protein first identified as a co-chaperone protein. TR-XAP2 interactions were TR isoform specific, being observed only with TRbeta1, and were enhanced by T(3) both in yeast and mammalian cells. Furthermore, small inhibitory RNA-mediated knockdown of XAP2 in vitro affected the stability of TRbeta1. In vivo, siXAP2 abrogated specifically TRbeta1-mediated (but not TRbeta2) activation of hypothalamic TRH transcription. This study provides the first in vivo demonstration of a regulatory, physiological role for XAP2."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400778"xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Becker N."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Berg P."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Demeneix B.A."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Sachs L.M."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Pongratz I."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Bilesimo P."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Seugnet I."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Nygard M."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Decherf S."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/author | "Froidevaux M.S."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/pages | "1035-1039"xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/title | "The co-chaperone XAP2 is required for activation of hypothalamic thyrotropin-releasing hormone transcription in vivo."xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16936638 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16936638 |
| http://purl.uniprot.org/citations/16936638 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16936638 |
| http://purl.uniprot.org/uniprot/#_D2CVN5-mappedCitation-16936638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16936638 |
| http://purl.uniprot.org/uniprot/#_A0A286YD21-mappedCitation-16936638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16936638 |
| http://purl.uniprot.org/uniprot/#_A0A286YDB1-mappedCitation-16936638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16936638 |
| http://purl.uniprot.org/uniprot/#_D3YW40-mappedCitation-16936638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16936638 |
| http://purl.uniprot.org/uniprot/#_P63058-mappedCitation-16936638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16936638 |