| http://purl.uniprot.org/citations/16938345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16938345 | http://www.w3.org/2000/01/rdf-schema#comment | "LAT is a linker protein essential for activation of T lymphocytes. Its rapid tyrosine-phosphorylation upon T cell receptor (TCR) stimulation recruits downstream signaling molecules for membrane targeting and activation. LAT is physically concentrated in cholesterol-enriched membrane microdomains and is known a substrate for Syk/Zap70 kinase. In this study, we demonstrate that LAT serves as a dual substrate for both Lck and Syk kinases. LAT phosphorylation is absent in Lck-deficient J.CaM1.6 cells and Lck is co-precipitated with LAT in pervanadate-activated Jurkat cells. Further, the in vitro kinase assay using purified Lck and LAT shows that Lck directly phosphorylates LAT. Both Lck and Syk, phosphorylate the ITAM-like motifs on LAT at Y171Y191, which is essential for induction of the interaction of LAT with downstream signaling molecules such as Grb2, PLC-gamma1 and c-Cbl, and for activation of MAPK-ERK. Collectively, our data indicate that LAT is an immediate substrate for Lck in one of the earliest events of T cell activation."xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.leukres.2006.07.010"xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/author | "Cheng H."xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/name | "Leuk Res"xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/pages | "541-545"xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/title | "Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16938345 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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