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| http://purl.uniprot.org/citations/16940169 | http://www.w3.org/2000/01/rdf-schema#comment | "Legionella pneumophila, the causative agent of Legionnaires' disease, grows within macrophages and manipulates target cell signaling. Formation of a Legionella-containing replication vacuole requires the function of the bacterial type IV secretion system (Dot/Icm), which transfers protein substrates into the host cell cytoplasm. A global microarray analysis was used to examine the response of human macrophage-like U937 cells to low-dose infections with L. pneumophila. The most striking change in expression was the Dot/Icm-dependent up-regulation of antiapoptotic genes positively controlled by the transcriptional regulator nuclear factor kappaB (NF-kappaB). Consistent with this finding, L. pneumophila triggered nuclear localization of NF-kappaB in human and mouse macrophages in a Dot/Icm-dependent manner. The mechanism of activation at low-dose infections involved a signaling pathway that occurred independently of the Toll-like receptor adaptor MyD88 and the cytoplasmic sensor Nod1. In contrast, high multiplicity of infection conditions caused a host cell response that masked the unique Dot/Icm-dependent activation of NF-kappaB. Inhibition of NF-kappaB translocation into the nucleus resulted in premature host cell death and termination of bacterial replication. In the absence of one antiapoptotic protein, plasminogen activator inhibitor-2, host cell death increased in response to L. pneumophila infection, indicating that induction of antiapoptotic genes is critical for host cell survival."xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20060766"xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/author | "Isberg R.R."xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/author | "Losick V.P."xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/pages | "2177-2189"xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/title | "NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila."xsd:string |
| http://purl.uniprot.org/citations/16940169 | http://purl.uniprot.org/core/volume | "203"xsd:string |
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