| http://purl.uniprot.org/citations/16940357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16940357 | http://www.w3.org/2000/01/rdf-schema#comment | "The mb1 gene encodes the Ig-alpha signaling subunit of the B cell antigen receptor and is expressed exclusively in B cells beginning at the very early pro-B cell stage in the bone marrow. We examine here the efficacy of the mb1 gene as a host locus for cre recombinase expression in B cells. We show that by integrating a humanized cre recombinase into the mb1 locus we obtain extraordinarily efficient recombination of loxP sites in the B cell lineage. The results from a variety of reporter genes including the splicing factor SRp20 and the DNA methylase Dnmt1 suggest that mb1-cre is probably the best model so far described for pan-B cell-specific cre expression. The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0605944103"xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Nielsen P.J."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Pelanda R."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Hobeika E."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Storch B."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/author | "Thiemann S."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/pages | "13789-13794"xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/title | "Testing gene function early in the B cell lineage in mb1-cre mice."xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/16940357 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16940357 |
| http://purl.uniprot.org/citations/16940357 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16940357 |
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| http://purl.uniprot.org/uniprot/#_Q3U1A5-mappedCitation-16940357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16940357 |
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