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| http://purl.uniprot.org/citations/16945999 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the mechanisms leading to transformation of early B-lineage precursors is an important step leading to rational design of new treatments for precursor (pre)-B-cell leukemia. We used normal mouse pre-B cells to determine if and how transforming growth factor (TGF)-beta1 affects these precursors to the B-cell lineage and whether transformed pre-B cells respond to TGF-beta1. We found that normal pre-B cells proliferating in the presence of interleukin (IL)-7 enter cell-cycle arrest after exposure to TGF-beta1. However, clonally related IL-7-independent tumors induced by oncogenes abl + myc or raf + myc have reduced sensitivity to TGF-beta1. In contrast, tumor cells induced by myc alone remain sensitive to TGF-beta1 growth suppression. These results suggest that lesions in different molecular signaling pathways can lead to loss of TGF-beta1 sensitivity in a single cell type. The approach of using normal pre-B-cell lines and transformation by overexpression of different oncogenes provides a system to compare and contrast molecular pathways that lead to full malignancy."xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.org/dc/terms/identifier | "doi:10.1634/stemcells.2005-0623"xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/author | "Bauer S.R."xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/author | "Rudikoff E."xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/author | "Letterio J."xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/author | "Voong N."xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/pages | "2611-2617"xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/title | "Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors."xsd:string |
| http://purl.uniprot.org/citations/16945999 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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