| http://purl.uniprot.org/citations/16950115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16950115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16950115 | http://www.w3.org/2000/01/rdf-schema#comment | "Early embryonic development depends on the faithful execution of basic cell biological processes whose coordination remains largely unknown. With a global network analysis, we found MEL-28 to be associated with two types of complexes, one implicated in nuclear-envelope function and the other in chromatin organization. Here, we show that MEL-28, a protein that shuttles between the nucleus and the kinetochore during the cell cycle, is required for the structural and functional integrity of the nuclear envelope. In addition, mel-28(RNAi) embryos exhibit defects in chromosome condensation, pronuclear migration, kinetochore assembly, and spindle assembly. This combination of mel-28(RNAi) phenotypes resemble those caused by depleting members of the Ran cycle in C. elegans, a conserved cellular signaling pathway that is required for mitotic spindle assembly, nuclear-envelope reformation after mitosis, and nucleocytoplasmic exchange (reviewed in). Although MEL-28 localization to the nuclear periphery is not dependent on nuclear pore components, it is dependent on RAN-1 and other key components of the Ran cycle. Thus, MEL-28 is downstream of the Ran cycle and is required for both proper nuclear-envelope function and chromatin maintenance."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.07.071"xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.07.071"xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/author | "Fernandez A.G."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/author | "Fernandez A.G."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/author | "Piano F."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/author | "Piano F."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/pages | "1757-1763"xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/pages | "1757-1763"xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/title | "MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/title | "MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance."xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/16950115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16950115 |
| http://purl.uniprot.org/citations/16950115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16950115 |
| http://purl.uniprot.org/citations/16950115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16950115 |
| http://purl.uniprot.org/citations/16950115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16950115 |
| http://purl.uniprot.org/citations/16950115 | http://purl.uniprot.org/core/erratum | http://purl.uniprot.org/citations/SIP2423385411D24AF2 |
| http://purl.uniprot.org/uniprot/Q18508 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16950115 |