| http://purl.uniprot.org/citations/16950847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16950847 | http://www.w3.org/2000/01/rdf-schema#comment | "The glutamate transporter GLT-1 from Rattus norvegicus was expressed at high level in baby hamster kidney (BHK-21) cells by the Semliki Forest Virus expression system. We examined the expressed GLT-1 in the plasma membrane and found that the transporter accumulates in detergent-insoluble lipid-protein assemblies. Freeze-fracture, immunogold labeling, and electron microscopy revealed that GLT-1 forms approximately 200-nm protein-rich islands in the plasma membrane. Cholesterol depletion in living cells resulted in a dispersion of the GLT-1 islands, indicating that they are the result of lipid-protein rather than protein-protein interactions. Disruption of GLT-1 islands and dispersion of GLT-1 goes along with a reduction of the glutamate transport activity. Our direct visualization of lipid-protein islands in the plasma membrane of tissue culture cells suggests that the reported clustering of glutamate transporters and their cholesterol-dependent transport activity in cells is likewise connected to their association with cholesterol-rich microdomains in the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.org/dc/terms/identifier | "doi:10.1529/biophysj.106.086900"xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/author | "Kuhlbrandt W."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/author | "Raunser S."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/author | "Haase W."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/author | "Franke C."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/author | "Muller W.E."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/author | "Eckert G.P."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/name | "Biophys J"xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/pages | "3718-3726"xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/title | "Heterologously expressed GLT-1 associates in approximately 200-nm protein-lipid islands."xsd:string |
| http://purl.uniprot.org/citations/16950847 | http://purl.uniprot.org/core/volume | "91"xsd:string |
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