| http://purl.uniprot.org/citations/16950879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16950879 | http://www.w3.org/2000/01/rdf-schema#comment | "In many animal species, germ-line progenitors associate with gonadal somatic cells to form the embryonic gonads (EGs) that later develop into functional organ producing gametes. To explore the genetic regulation of the germ-line development, we initiated a comprehensive identification and functional analysis of the genes expressed within the EGs. First, we generated a cDNA library from gonads purified from Drosophila embryos by FACS. Using this library, we catalogued the genes expressed in the gonad by EST analysis. A total of 17,218 high-quality ESTs representing 3,051 genes were obtained, corresponding to 20% of the predicted genes in the genome. The EG transcriptome is unexpectedly distinct from that of adult gonads and includes an extremely high proportion of retrotransposon-derived transcripts. We verified 101 genes preferentially expressed in the EGs by whole-mount in situ hybridization. Within this subset, 39 and 58 genes were expressed predominantly in germ-line and somatic cells, respectively, whereas four genes were expressed in the both cell lineages. The gonad-enriched genes encompassed a variety of predicted functions. However, genes implicated in SUMOylation and protein translation, including germ-line-specific ribosomal proteins, are preferentially expressed in the germ line, whereas the expression of various retrotransposons and RNAi-related genes are more prominent in the gonadal soma. These transcriptome data are a resource for understanding the mechanism of various cellular events during germ-line development."xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0603767103"xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/author | "Shigenobu S."xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/author | "Noda C."xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/author | "Kitadate Y."xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/pages | "13728-13733"xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/title | "Molecular characterization of embryonic gonads by gene expression profiling in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/16950879 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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