| http://purl.uniprot.org/citations/16951045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16951045 | http://www.w3.org/2000/01/rdf-schema#comment | "The intracellular signaling of human urotensin II (hU-II) and its interaction with other vasoconstrictors such as ANG II are poorly understood. In endothelium-denuded rat aorta, coadministration of hU-II (1 nM) and ANG II (2 nM) exerted a significant contractile effect that was associated with increased protein kinase C (PKC) activity and phosphorylation of PKC-alpha/betaII and myosin light chain, whereas either hU-II or ANG II administered alone at these concentrations had no statistically significant effect. This synergistic effect was abrogated by the PKC inhibitor chelerythrine (10 and 30 microM), the selective PKC-alpha/betaII inhibitor Gö-6976 (0.1 and 1 microM), the hU-II receptor ligand urantide (30 nM and 1 microM), or the ANG II antagonist losartan (1 microM). Moreover, in endothelium-intact rat aorta, the synergistic effect of hU-II and ANG II was not exerted any longer, and this synergistic effect was unmasked by pretreatment of the nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester. hU-II (10 nM) alone caused a long-lasting increase in phospho-PKC-theta, phospho-myosin light chain, and PKC activity, which was associated with long-lasting vasoconstriction. These changes were prevented by chelerythrine. Methoxyverapamil-thapsigargin treatment reduced the hU-II-induced vasoconstriction by approximately 50%. The methoxyverapamil-thapsigargin-resistant component of hU-II-induced vasoconstriction was dose-dependently inhibited by chelerythrine. In conclusion, hU-II induces a novel PKC-dependent synergistic action with ANG II in inducing vasoconstriction. PKC-alpha/betaII is probably the PKC isoform involved in this synergistic action. Nitric oxide produced in the endothelium probably masks this synergistic action. The long-lasting vasoconstriction induced by hU-II alone is PKC dependent and associated with PKC-theta phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00512.2006"xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/author | "Wang Y.X."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/author | "Zhu Y.Z."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/author | "Yao T."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/author | "Zhu Y.C."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/author | "Ding Y.J."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/pages | "H348-59"xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/title | "Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction."xsd:string |
| http://purl.uniprot.org/citations/16951045 | http://purl.uniprot.org/core/volume | "292"xsd:string |
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