| http://purl.uniprot.org/citations/16951688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16951688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16951688 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta1 (TGF-beta1) is a potent cytokine with pleiotropic effects, including anti-inflammatory activity. Here we show that the signaling protein Smad6 bound to Pellino-1, an adaptor protein of mammalian interleukin 1 receptor (IL-1R)-associated kinase 1 (IRAK1), and thereby promoted TGF-beta-mediated anti-inflammatory effects. Smad6-Pellino-1 interaction abrogated signaling mediated by a complex of IRAK1, Pellino-1 and adaptor protein TRAF6 that formed after stimulation by IL-1beta treatment. Blockade of IRAK1-Pellino-1-TRAF6 signaling prevented degradation of the inhibitor IkappaBalpha and subsequent nuclear translocation of transcription factor NF-kappaB and thus expression of proinflammatory genes. 'Knockdown' of endogenous Smad6 expression by RNA interference reduced anti-inflammatory activity mediated by TGF-beta1 or the TGF-beta family member BMP-4. Thus Smad6 is a critical mediator of the TGF-beta-BMP pathway that mediates anti-inflammatory activity and negatively regulates IL-1R-Toll-like receptor signals."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1383"xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1383"xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Hong S."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Hong S."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Choi H.K."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Choi H.K."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lim S."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lim S."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lee E.K."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Lee E.K."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Choi K.C."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Choi K.C."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Kim I.H."xsd:string |
| http://purl.uniprot.org/citations/16951688 | http://purl.uniprot.org/core/author | "Kim I.H."xsd:string |