| http://purl.uniprot.org/citations/16954505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16954505 | http://www.w3.org/2000/01/rdf-schema#comment | "Genes that are strongly repressed after B-cell activation are candidates for being inactivated, mutated, or repressed in B-cell malignancies. Krüppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell lineage lymphomas and leukemias. The human KLF4 gene has been identified as a tumor suppressor gene in colon and gastric cancer; in concordance with this, overexpression of KLF4 can suppress proliferation in several epithelial cell types. Here we investigate the effects of KLF4 on pro/pre-B-cell transformation by v-Abl and BCR-ABL, oncogenes that cause leukemia in mice and humans. We show that overexpression of KLF4 induces arrest and apoptosis in the G1 phase of the cell cycle. KLF4-mediated death, but not cell-cycle arrest, can be rescued by Bcl-XL overexpression. Transformed pro/pre-B cells expressing KLF4 display increased expression of p21CIP and decreased expression of c-Myc and cyclin D2. Tetracycline-inducible expression of KLF4 in B-cell progenitors of transgenic mice blocks transformation by BCR-ABL and depletes leukemic pre-B cells in vivo. Collectively, our work identifies KLF4 as a putative tumor suppressor in B-cell malignancies."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-03-011106"xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Yang V.W."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Huettner C.S."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Segre J.A."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Fruman D.A."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Kharas M.G."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Yusuf I."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/author | "Scarfone V.M."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/pages | "747-755"xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/title | "KLF4 suppresses transformation of pre-B cells by ABL oncogenes."xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/16954505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16954505 |
| http://purl.uniprot.org/citations/16954505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16954505 |
| http://purl.uniprot.org/uniprot/#_B7ZCH1-mappedCitation-16954505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16954505 |
| http://purl.uniprot.org/uniprot/#_B7ZCH2-mappedCitation-16954505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16954505 |
| http://purl.uniprot.org/uniprot/#_Q60793-mappedCitation-16954505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16954505 |
| http://purl.uniprot.org/uniprot/Q60793 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16954505 |
| http://purl.uniprot.org/uniprot/B7ZCH2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16954505 |
| http://purl.uniprot.org/uniprot/B7ZCH1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16954505 |