| http://purl.uniprot.org/citations/16959241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16959241 | http://www.w3.org/2000/01/rdf-schema#comment | "During vertebrate retinal development, the seven retinal cell types differentiate sequentially from a single population of retinal progenitor cells (RPCs) and organize themselves into a distinct laminar structure. The purpose of this study was to determine whether beta-catenin, which functions both as a nuclear effector for the canonical Wnt signaling pathway and as a regulator of cell adhesion, is required for retinal neurogenesis or lamination. We used the Cre-loxP system to either eliminate beta-catenin or to express a constitutively active form during retinal neurogenesis. Eliminating beta-catenin did not affect cell differentiation, but did result in the loss of the radial arrangement of RPCs and caused abnormal migration of differentiated neurons. As a result, the laminar structure was massively disrupted in beta-catenin-null retinas, although all retinal cell types still formed. In contrast to other neural tissues, eliminating beta-catenin did not significantly reduce the proliferation rate of RPCs; likewise, activating beta-catenin ectopically in RPCs did not result in overproliferation, but loss of neural retinal identity. These results indicate that beta-catenin is essential during retinal neurogenesis as a regulator of cell adhesion but not as a nuclear effector of the canonical Wnt signaling pathway. The results further imply that retinal lamination and retinal cell differentiation are genetically separable processes."xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.08.015"xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/author | "Mu X."xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/author | "Fu X."xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/author | "Klein W.H."xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/pages | "424-437"xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/title | "Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development."xsd:string |
| http://purl.uniprot.org/citations/16959241 | http://purl.uniprot.org/core/volume | "299"xsd:string |
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