| http://purl.uniprot.org/citations/16959576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16959576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16959576 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Mutations in presenilins 1 and 2 (PS1 and PS2) account for approximately 40% of familial AD (FAD) cases. FAD mutations and genetic deletions of presenilins have been associated with calcium (Ca(2+)) signaling abnormalities. We demonstrate that wild-type presenilins, but not PS1-M146V and PS2-N141I FAD mutants, can form low-conductance divalent-cation-permeable ion channels in planar lipid bilayers. In experiments with PS1/2 double knockout (DKO) mouse embryonic fibroblasts (MEFs), we find that presenilins account for approximately 80% of passive Ca(2+) leak from the endoplasmic reticulum. Deficient Ca(2+) signaling in DKO MEFs can be rescued by expression of wild-type PS1 or PS2 but not by expression of PS1-M146V or PS2-N141I mutants. The ER Ca(2+) leak function of presenilins is independent of their gamma-secretase activity. Our data suggest a Ca(2+) signaling function for presenilins and provide support for the "Ca(2+) hypothesis of AD.""xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.06.059"xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.06.059"xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Yu G."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Yu G."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Tu H."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Tu H."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "De Strooper B."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "De Strooper B."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Lee S.F."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Lee S.F."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Serneels L."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Serneels L."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Bezprozvanny I."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Bezprozvanny I."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Nelson O."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Nelson O."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Hao Y.H."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Hao Y.H."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Bezprozvanny A."xsd:string |
| http://purl.uniprot.org/citations/16959576 | http://purl.uniprot.org/core/author | "Bezprozvanny A."xsd:string |