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http://purl.uniprot.org/citations/16961714http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16961714http://www.w3.org/2000/01/rdf-schema#comment"

Background

Asthma is a multi-factorial disorder caused by complex interactions between genetic and environmental factors. IFN-gamma and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma.

Objective

This study investigated CA repeats polymorphism of the IFN-gamma gene and GT repeats polymorphism of the IRF-1 gene, which may predispose individuals to asthma pathogenesis.

Methods

In the present study, we used the transmission/disequilibrium test (TDT) to investigate the relationship between asthma and the IFN-gamma and IRF-1 polymorphisms by studying 348 subjects composed of 232 parents and 116 asthmatic children.

Results

For global TDT test, IFN-gamma CA repeats and IRF-1 GT repeat polymorphisms showed a significant association with asthma in children (P=0.009 and 0.017, respectively). We demonstrated that 13 CA repeats (138 bp) of IFN-gamma gene and 11 GT repeats (306 bp) of IRF-1 gene are significantly preferentially transmitted to asthmatic children (T/NT=89/61, chi2=8.43, P<0.005 and T/NT=75/49, chi2=8.18, P<0.005, respectively). The offspring will have an increased risk of asthma when their parents transmit IFN-gamma 13 CA repeats (OR=1.83, P=0.009) and IRF1 11 GT repeats (OR=1.88, P=0.007) to them. But we observed that the IFN-gamma and IRF-1 polymorphisms are not associated with IgE concentrations.

Conclusion

These findings provide strong evidence of which IFN-gamma CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2222.2006.02551.x"xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Ko Y.C."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Chen W.Y."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Chu Y.T."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Wang T.N."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Hsiang C.H."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Feng W.W."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/author"Shih N.H."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/name"Clin Exp Allergy"xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/pages"1147-1152"xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/title"Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan."xsd:string
http://purl.uniprot.org/citations/16961714http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/16961714http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16961714
http://purl.uniprot.org/citations/16961714http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16961714
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http://purl.uniprot.org/uniprot/#_A0A1B1RS94-mappedCitation-16961714http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16961714
http://purl.uniprot.org/uniprot/#_A0A510GDD8-mappedCitation-16961714http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16961714
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