| http://purl.uniprot.org/citations/16962829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16962829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16962829 | http://www.w3.org/2000/01/rdf-schema#comment | "The rapamycin-insensitive mTOR complex 2 (mTORC2) has been suggested to play an important role in growth factor-dependent signaling. To explore this possibility further in a mammalian model system, we disrupted the expression of rictor, a specific component of mTORC2, in mice by using a multiallelic gene targeting strategy. Embryos that lack rictor develop normally until E9.5, and then exhibit growth arrest and die by E11.5. Although placental defects occur in null embryos, an epiblast-specific knockout of rictor only delayed lethality by a few days, thereby suggesting other important roles for this complex in the embryo proper. Analyses of rictor null embryos and fibroblasts indicate that mTORC2 is a primary kinase for Ser473 of Akt/PKB. Rictor null fibroblasts exhibit low proliferation rates, impaired Akt/PKB activity, and diminished metabolic activity. Taken together, these findings indicate that both rictor and mTORC2 are essential for the development of both embryonic and extraembryonic tissues."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2006.08.013"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2006.08.013"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Magnuson M.A."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Magnuson M.A."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Lindner J."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Lindner J."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Shiota C."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Shiota C."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Shelton K.D."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Shelton K.D."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Woo J.-T."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/author | "Woo J.-T."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/pages | "583-589"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/pages | "583-589"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/title | "Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/title | "Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability."xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/16962829 | http://purl.uniprot.org/core/volume | "11"xsd:string |