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Background

Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk.

Methods

The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms-PCR-RFLP, PCR-INVADER, or Sequenom.

Results

None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR=1.21, 95% CI: 0.78-1.88); Arg399Gln (OR=1.20, 95% CI: 0.80-1.79); XRCC3: Thr241Met (OR=1.04, 95% CI: 0.76-1.41).

Conclusions

These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer."xsd:string
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http://purl.uniprot.org/citations/16963196http://purl.uniprot.org/core/author"Anderson K.E."xsd:string
http://purl.uniprot.org/citations/16963196http://purl.uniprot.org/core/author"Gross M.D."xsd:string
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http://purl.uniprot.org/citations/16963196http://purl.uniprot.org/core/name"Cancer Detect Prev"xsd:string
http://purl.uniprot.org/citations/16963196http://purl.uniprot.org/core/pages"313-321"xsd:string
http://purl.uniprot.org/citations/16963196http://purl.uniprot.org/core/title"No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study."xsd:string
http://purl.uniprot.org/citations/16963196http://purl.uniprot.org/core/volume"30"xsd:string
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