| http://purl.uniprot.org/citations/16963626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16963626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16963626 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified genes encoding candidate proteins involved in iron storage (pcl1+), the tricarboxylic acid cycle (sdh4+), and iron-sulfur cluster assembly (isa1+) that are negatively regulated in response to iron deprivation. Promoter deletion and site-directed mutagenesis permitted identification of a new cis-regulatory element in the promoter region of the pcl1+ gene. This cis-acting regulatory sequence containing the pentanucleotide sequence CCAAT is responsible for transcriptional repression of pcl1+ under low iron supply conditions. In Schizosaccharomyces pombe, the CCAAT-binding factor is a heteromeric DNA-binding complex that contains three subunits, designated Php2, Php3, and Php5. Inactivation of the php2+ locus negatively affects the transcriptional competency of pcl1+. A fourth subunit, designated Php4, is not essential for the transcriptional activation of target genes under basal and iron-replete conditions. We demonstrate that, in response to iron-limiting conditions, Php4 is required for down-regulation of pcl1+, sdh4+, and isa1+ mRNA levels. In vivo RNase protection studies reveal that the expression of php4+ is negatively regulated by iron and that this regulated expression requires a functional fep1+ gene. The results of these studies reveal that Fep1 represses php4+ expression in response to iron. In contrast, when iron is scarce, Fep1 becomes inactive and php4+ is expressed to act as a regulatory subunit of the CCAAT-binding factor that is required to block pcl1+, sdh4+, and isa1+ gene transcription."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.org/dc/terms/identifier | "doi:10.1128/ec.00199-06"xsd:string |
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| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/author | "Labbe S."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/author | "Labbe S."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/author | "Mercier A."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/author | "Mercier A."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/author | "Pelletier B."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/author | "Pelletier B."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/name | "Eukaryot. Cell"xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/name | "Eukaryot. Cell"xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/pages | "1866-1881"xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/pages | "1866-1881"xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/title | "A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/title | "A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/16963626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16963626 |
| http://purl.uniprot.org/citations/16963626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16963626 |
| http://purl.uniprot.org/citations/16963626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16963626 |
| http://purl.uniprot.org/citations/16963626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16963626 |