| http://purl.uniprot.org/citations/16964259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16964259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16964259 | http://www.w3.org/2000/01/rdf-schema#comment | "The Mediator head module stimulates basal RNA polymerase II (Pol II) transcription and enables transcriptional regulation. Here we show that the head subunits Med8, Med18 and Med20 form a subcomplex (Med8/18/20) with two submodules. The highly conserved N-terminal domain of Med8 forms one submodule that binds the TATA box-binding protein (TBP) in vitro and is essential in vivo. The second submodule consists of the C-terminal region of Med8 (Med8C), Med18 and Med20. X-ray analysis of this submodule reveals that Med18 and Med20 form related beta-barrel folds. A conserved putative protein-interaction face on the Med8C/18/20 submodule includes sites altered by srb mutations, which counteract defects resulting from Pol II truncation. Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation-complex formation and suggest that the Mediator head contains a multipartite TBP-binding site that can be modulated by transcriptional activators."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1143"xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1143"xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Cramer P."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Cramer P."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Hoeppner S."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Hoeppner S."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Lariviere L."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Lariviere L."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Roether S."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Roether S."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Straesser K."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Straesser K."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Geiger S."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/author | "Geiger S."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/pages | "895-901"xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/pages | "895-901"xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/title | "Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20."xsd:string |
| http://purl.uniprot.org/citations/16964259 | http://purl.uniprot.org/core/title | "Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20."xsd:string |