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| http://purl.uniprot.org/citations/16966372 | http://www.w3.org/2000/01/rdf-schema#comment | "The src family kinases p56lck (Lck) and p59fyn (Fyn) are the most proximal signaling molecules to be activated downstream of the T-cell receptor. Using an inducible transgenic model, we can regulate the expression of Lck in primary T cells and ask how the signaling cascade and differentiation potential are affected by the absence or the presence of reduced levels of Lck. We show that in naïve T cells, Lck controls the threshold of activation by preferentially regulating multiple signaling pathways that result in the mobilization of Ca2+ through activation of phospholipase C-gamma and protein kinase C as well as activation of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. Fyn is also able to stimulate the ERK/MAPK pathway in primary T cells but has little influence on the mobilization of Ca2+. Only Lck efficiently stimulates production of diacylglycerol and therefore RasGRP1 recruitment to the plasma membrane and phosphorylation of Shc, suggesting that Fyn activates ERK via a different upstream signaling route. Finally, we show that signals through Lck are essential for the development of T-cell-effector potential, particularly for effective cytokine transcription."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00168-06"xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/author | "Palmer E."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/author | "Zamoyska R."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/author | "Parravicini V."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/author | "Filby A."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/author | "Lovatt M."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/author | "Werlen G."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/pages | "8655-8665"xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/title | "Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response."xsd:string |
| http://purl.uniprot.org/citations/16966372 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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