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| http://purl.uniprot.org/citations/16966473 | http://www.w3.org/2000/01/rdf-schema#comment | "Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K(+) channels and has been proposed to be the acute O(2) sensor in the carotid body (CB). We have tested the physiological contribution of this enzyme to O(2) sensing using HO-2 null mice. HO-2 deficiency leads to a CB phenotype characterized by organ growth and alteration in the expression of stress-dependent genes, including the maxi-K(+) channel alpha-subunit. However, sensitivity to hypoxia of CB is remarkably similar in HO-2 null animals and their control littermates. Moreover, the response to hypoxia in mouse and rat CB cells was maintained after blockade of maxi-K(+) channels with iberiotoxin. Hypoxia responsiveness of the adrenal medulla (AM) (another acutely responding O(2)-sensitive organ) was also unaltered by HO-2 deficiency. Our data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K(+) channel gene expression but it does not alter the intrinsic O(2) sensitivity of CB or AM cells. Therefore, HO-2 is not a universally used acute O(2) sensor."xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.org/dc/terms/identifier | "doi:10.1085/jgp.200609591"xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/author | "Pascual A."xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/author | "Lopez-Barneo J."xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/author | "Ortega-Saenz P."xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/author | "Gomez-Diaz R."xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/name | "J Gen Physiol"xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/pages | "405-411"xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/title | "Acute oxygen sensing in heme oxygenase-2 null mice."xsd:string |
| http://purl.uniprot.org/citations/16966473 | http://purl.uniprot.org/core/volume | "128"xsd:string |
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